Jing Chen

Lab Website: Chen Research Group
Publications: Google Scholar

The Chen Lab builds mathematical models to study cell biology, especially how spatial, temporal and mechanical regulations couple with signaling pathways to control cellular functions. Biological systems self-assemble into highly heterogeneous and dynamic structures. Spatiotemporal regulation and mechanical interactions constitute integrated components of biological signaling mechanisms, but in most cases their functional roles are not well understood yet. Modern experimental tools allow high resolution live-cell imaging and dynamic force measurement; however, it remains difficult or impossible to simultaneously track all biomolecules and their activities in the complex biological systems. To fill the unavoidable void, we weave experimental data into physically viable models, which provides insights into functional roles of spatiotemporal regulation and mechanical interactions. We typically work in close collaboration with experimental groups to ensure effective feedback between theory and experiments.

Biological Sciences | College of Science | Bacterial Motility | Cell Division Mechanism | Circadian Gene Expression | Mathematical Modeling | Pattern Formation in Microbial Community | Theoretical and Computational Cell Biology