Sohan Kale

Lab Website: Mechanics of Living Materials Lab
Publications: Google Scholar

The research at Dr. Kale’s Mechanics of Living Materials Lab is rooted in theoretical and computational mechanics, with a focus on systems at the intersection of engineering and biology. We develop mathematical and computational models of coupled chemomechanical phenomena relevant to cytoskeletal mechanics, cell migration, mechanics of multicellular systems, microbial adhesion, and tissue growth. ­We implement continuum and discrete models at subcellular, cellular, and tissue scales and use homogenization approaches to connect behaviors at different length scales. We also develop inverse methods and data-driven approaches that enable the measurement of traction forces exerted by migrating cells and the estimation of membrane tension in inflated cellular sheets. The overarching goal of our research is to understand the ‘structure-property-function’ relationship to design, control, and rationally manipulate living materials for challenges in health and novel engineering applications.

Mechanobiology | Soft/Active Matter | Computational Mechanics | Multiscale Modeling | Continuum Thermomechanics